The Sutterwala and Cassel labs ( https://www.cedars-sinai.edu/Research/Research-Labs/Sutterwala-and-Cassel-Lab/ ) are recruiting postdoctoral fellows to study NLR biology in innate and adaptive immune responses and also non-immunological roles such as senescence and tissue repair. Research projects include characterization of novel phenotypes in genetically modified animals and determining the mechanisms that create the in vivo findings. Some examples of ongoing research projects include:
1) Evaluating the contribution of mitophagy and mitochondrial haplogroups in innate immune signaling (Elliott et al. J Immunol 2018; Iyer et al. Immunity 2013). 2) Defining the role of macrophage NLRC4 in controlling anti-tumor CD4 and CD8 T cell responses (Janowski et al. J Clin Invest 2016). 3) Evaluation of NLR function in cellular senescence in a model of acute lung injury. 4) Determining the mechanism of NLRP12-mediated recruitment of neutrophils to inflammatory sites (Ulland et al. Nat Commun 2016).
Summary: Working independently but in close cooperation and in consultation with the Principal Investigator and other Research Scientist, the Research Fellow will perform routine and complex laboratory procedures throughout training period. May develop, adapt, and implement new research techniques and protocols. Analyzes and interprets data. May assist in preparation of grant proposals. Participates in publications and presentations as author or co-author. Not responsible for generating grant funds.
Essential Job Duties and Responsibilities:
May assist in preparation of grant proposals, but is not responsible for generating grant funds. May participate in publications and presentations as author or co-author. Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator. May develop, adapt, and implement new research techniques and protocols. Analyzes, interprets, summarizes and compiles data. Performs routine and complex laboratory procedures throughout training period. Operates and maintains equipment and instruments.
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research... and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major teaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.