In the Neurodegenerative Diseases Laboratory led by Robert Baloh, MD, PhD, the goal is to understand mechanisms of neurodegenerative diseases including amyotrophic lateral sclerosis and peripheral neuropathy using human disease genes as our guide, in an effort to develop effective treatments for these disorders.
The Baloh Lab is currently seeking a Postdoctoral Scientist to study the molecular mechanisms of neurodegeneration with focus on mitochondrial function and dynamics and their role in axonal and cellular integrity. This is an excellent opportunity to work with a multidisciplinary group of neurologists, molecular biologists and neurogeneticists interested in understanding neurodegeneration with the goal of developing therapies. The primary focus of the Postdoctoral Scientist will be studying molecular mechanisms of neurodegeneration resulting from altered mitochondrial dynamics, which impacts a range of diseases including inherited neuropathy, motor neuron disease/ALS, Parkinson's and Alzheimer's disease.
The ideal candidate will have experience with:
A broad range of techniques including molecular biology and genetic engineering, mitochondrial analysis and live cell imaging, tissue culture including iPSC differentiation, transcriptomic analysis, and disease modeling in rodents
Performing routine and complex laboratory procedures throughout the training period
Developing, adapting, and implementing new research techniques and protocols, and analyzing and interpreting data
Participating in publications and presentations as author or co-author
Additional Expectations and Job Duties:
May assist in preparation of grant proposals, but is not responsible for generating grant funds
Designs and performs experiments, keeping appropriate experimental records and documentation and analyze the results with the Principal Investigator
May develop, adapt, and implement new research techniques and protocols
Operates and maintains equipment and instruments
Participation in laboratory meetings, keeping a lab notebook, performing calculations, tabulating data, summarizing methods and results of related experiments and general lab maintenance
Function efficiently and cooperatively with a team of faculty, research associates, technicians and students
Scheduling flexibility to include evening, weekend and holiday rotation commitment is required
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research... and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major teaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.