The Knott Lab is searching for a computational biologist post-doctoral scientist that is interested in applying single cell profiling technologies to study breast cancer progression. We are part of the Center for Bioinformatics and Functional Genomics at Cedars Sinai Medical Institute, in Los Angeles California. The lab is currently focused on developing molecular and computational tools to study the mechanisms that cancer cells employ to metastasize and evade therapy. We are particularly interested in next-generation therapeutics that target the interactions between malignant and non-malignant tumor cell types, such as immune checkpoint inhibitors.
The chosen candidate will work alongside oncologists and bench scientists to generate clinically actionable hypotheses from novel single cell datasets. These will include 10X genomics data from dissociated tumors as well as information from in situ experiments, where single cell expression profiles are extracted from intact tumor tissue. In addition, the selected applicant will be a key contributor to the design and data analysis portion of follow-up validation studies, which employ our novel genome-wide CRISPR reagents. This position offers a unique opportunity for a post doc with a computational specialty to fully immerse themselves in the discovery process.
Develop and employ a variety of computational tools to analyze single cell expression profiling data.
Develop, implement and adapt software tools to analyze single cell genomic and proteomic data
Analyze, interpret and summarize single cell data
Participate present findings in weekly meetings
Publish findings in peer reviewed journal
Attend present findings at scientific meetings in and outside of the Los Angeles area
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research... and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major teaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.