The applicant will assist in the biological and biochemical analysis of the renin-angiotensin system. Work will focus on the immunologic, biochemical and metabolic effects of angiotensin converting enzyme (ACE) on myeloid cells. Several studies from our group has shown that ACE over expression in myeloid cells markedly enhances the function of macrophages and neutrophils (reviewed in Angiotensin-converting enzyme in innate and adaptive immunity. Bernstein KE, Khan Z, Giani JF, et al. Nat Rev Nephrol. 2018 May;14(5):325-336). Our group has recently received an NIH grant to study the mechanism by which ACE causes this effect. We will be pursuing a number of independent avenues, including the effects of ACE on the metabolism of cells. The applicant will be expected to do:
Planning, designing, and executing experiments. Includes data interpretation and analysis, and troubleshooting in areas of molecular biology, recombinant techniques, biochemistry, cell culture, RNAi, in vivo techniques, microscopy and molecular imaging. May develop, adapt, and implement new research techniques and protocols.
Regular meetings with PI to discuss experimental plans and results.
Attendance and participation at regularly scheduled lab meetings and conferences.
Presentation and dissemination of research through oral presentations at internal and external meetings, and writing original research articles for publication in scientific journals.
Applies for appropriate and eligible fellowship funding and contribution toward acquisition of lab funding for gene and drug delivery research.
Participation in training of junior lab members.
Contribution to general lab maintenance.
Upkeep of well-organized lab book.
May assist in preparation of grant proposals, but is not responsible for generating grant funds.
May participate in publications and presentations as author or co-author.
Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
Analyzes, interprets, summarizes and compiles data.
Performs routine and complex laboratory procedures throughout training period.
Operates and maintains equipment and instruments
A doctorate degree (MD or PhD)
Works independently on research projects designed by a mentor (typically the PI) within the area of specialization. Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year postdoctoral appointment. Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis and operation and maintenance of specialized equipment. Knowledge of safety standards and maintenance of specialized equipment.
In addition to professional development opportunities, Cedars-Sinai offers competitive compensation and benefits package: Medical, Dental, 403(b) with match in addition to Cedars-Sinai’s paid Retirement Program, Tuition Assistance, Credit Union, Wellbeing Program Rideshare, Employee Discounts, Healthcare and Dependent Care Reimbursement Accounts, Group Life/AD&D and Long Term Disability Insurance, start at 16 vacation days/year.
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research... and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major teaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.