The Theodorescu Lab at Cedars-Sinai in Los Angeles, along with collaborators, has made significant contributions in the areas of telomerase biology. These contribtuions include finding a high frequency of TERT promoter mutations (Clin Cancer Res. 2014 20(18):4935), the impact of these TERT mutations on TERT expression, and the clinical relevance of these mutations in patients (Science. 2015;347(6225):1006). Further discoveries have been made in TERT regulation (Genes Dev. 2015 29(21):2219). We are seeking a highly motivated individual to further develop this work as well as discover and investigate the role of TERT, its regulators and effectors, in cancer progression and metastasis. In addition, the laboratory has ongoing drug discovery projects directed at key molecules involved in telomerase biology which may interest the individual. The successful candidate will have a PhD degree and background in telomerase biology or related field as well as in functional genomics (including CRISPR, shRNA and cDNA library use), signal transduction and biochemistry/chemistry or related fields. We welcome applications who are completing their PhD as well as individuals seeking additional postdoctoral training. Strong preference will be given to individuals with an outstanding publication record from their prior graduate and/or postgraduate training and/or existing extramural funding.
ESSENTIAL JOB DUTIES AND RESPONSIBILITIES:
May assist in preparation of grant proposals, but is not responsible for generating grant funds.
Participates in publications and presentations as author or co-author.
Designs and performs experiments. Keeps detailed experimental records and documentation and analyze the results with the Principal Investigator.
Develops, adapts, and implements new research techniques and protocols.
Analyzes, interprets, summarizes and compiles data.
Performs routine and complex laboratory procedures throughout training period.
Meets with Dr. Theodorescu on a regular basis to discuss research progress and plans.
May be asked to write small grant proposals or NRSA/T32 applications.
Spends about 75% of time on bench research experimentation and 25% of time on writing articles/analyzing data/online research.
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research... and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major teaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.